Myoglobin /CK-MB/ Troponin I combined test sheet, blood/serum/plasma sample - 25pcs

Myoglobin (MYO), creatine kinase-MB (CK-MB) and myocardial troponin I (cTnI) are proteins that are released into the blood when the heart muscle is damaged. Myoglobin is a haemoprotein with a molecular weight of 17.8 kDa found in skeletal and cardiac muscle1.

When muscle cells are injured, the relatively small size of the myoglobin released means that it is rapidly released into the blood. Myoglobin levels increase measurably from baseline 2-4 hours after infarction, reaching a maximum value 9-12 hours after infarction and returning to baseline 24-36 hours after infarction2,3. Creatine kinase is a dimeric enzyme with two subunits located in the muscle "M" and in the brain "B", which together form three different isoenzymes: CK-MM, CK-BB, and CK-MB. CK-MB is the most important isoenzyme of creatinine kinase for the detection of myocardial damage.5 CK-MB is a fairly accurate marker of myocardial infarction5. 3-8 hours after the onset of myocardial infarction symptoms, CK-MB levels in the blood increase, reaching a maximum value between 9-30 hours after myocardial damage. Myocardial troponin I (cTnI) is a protein of 22.5 kDa molecular weight located in the myocardium7. Troponin I is a subunit of the three-part complex Troponin I, Troponin T and Troponin C. Together with tropomyosin, this structural complex is the main regulator of calcium-sensitive ATPase activity of actomyosin in cardiac and striated muscle8. Troponin I is released and released into the blood 4-6 hours after the onset of pain due to myocardial injury. The release of Troponin I and CK-MB are similar, but while CK-MB levels fall to normal within 72 hours, Troponin I levels remain elevated for 6-10 days, giving a longer period for detection of myocardial injury.

The Myoglobin/CK-MB/Troponin I Combo Rapid Test Card (Whole Blood/Serum/Plasma) uses a complex reaction of combined antibody-coated particles and reagents for the qualitative detection of Myoglobin, CK-MB and Troponin I (cTnI) from whole blood, serum or plasma. The minimum detectable concentrations are 50 ng/ml Myoglobin, 5 ng/ml CK-MB and 0,5 ng/ml Troponin I.